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[DOI] [PubMed] [Google Scholar] 134.Busetto L, Bettini S, Makaronidis J, et al

As you can see, the math is straightforward, but you have to be meticulous

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While the number of blockbusters (asset-indications forecast to achieve peak sales greater than $1 billion) has decreased to 108 in 2025, down from 111 in 2024, the number of mega-blockbusters (asset-indications forecasts to achieve peak sales greater than $10 billion) has increased from six in 2024 to eight in 2025