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FOXO4-DRI is a D-amino acid retro-inverso peptide that disrupts the intracellular interaction between FOXO4 and p53 in senescent cells, triggering p53-mediated apoptosis selectively in senescent rather than healthy proliferating cells

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Among them, the MC3181 derivative was recently found to be extremely efficient in blocking cancer growth and metastasis in a xenograft mouse model of vemurafenib resistant melanoma (Fig