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Mechanistically, GHK-Cu has been shown to stimulate collagen and elastin synthesis in dermal fibroblasts, increase decorin (a small proteoglycan that helps regulate collagen organization), and influence matrix metalloproteinases and their inhibitors

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Each improvement builds on the others, creating momentum toward better cardiovascular health

While leg pain is not listed as a primary side effect in clinical trials, individual reports suggest dehydration, electrolyte shifts, and rapid weight loss may contribute to muscle tension