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Hepatotoxicity elevation of liver enzymes and rare instances of hepatic dysfunction

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Effect of weekly subcutaneous semaglutide vs daily liraglutide on body weight or obesity with-out diabetes

The mode of action for AMG133 is believed to involve this bispecific molecule simultaneously binding to both the GIP- and GLP-1 receptor, where it is demonstrated to increase cAMP production and induce internalization of co-localized GIP and GLP-1 receptors