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data suggests that in late disease, its advantages may disappear or even turn harmful (234)

Health Canada cleared it for the same indication as brand Ozempic: once-weekly treatment of Type 2 diabetes in adults

He notes that in humans GLP-1 reduces pancreatic inflammation and rarely increases amylase and lipase to more than the 3- fold increase which is needed to meet diagnostic criteria for pancreatitis

The lower VO 2max in patients was not due to submaximal effort during the exercise test, as the proportion of participants attaining a plateau in VO 2 did not differ between groups, the gas exchange threshold was at similar percentages of VO 2max , and secondary criteria ([lactate], maximal RER and heart rate) were attained in both groups (Supplemental Fig