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159 Multiple Wnt/-catenin signalling-related genes are hypermethylated in the brains of PD patients, including its receptor LRP5, the transcription factor TCF7L2, the inhibitors FRZB, SFRP1, and SFRP2, and multiple target genes

Evidence-based stress reduction approaches include regular physical activity, meditation, progressive muscle relaxation, and when appropriate, psychotherapy for underlying anxiety or mood disorders

Furthermore, GLP-1RA showed a tendency for increased efficacy than TZD in reducing NAS and fibrosis stage, resolving NASH, decreasing liver fat content measured using CAP, and improving liver function parameters and glucose levels

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