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doi:10.1073/pnas.1205227109 44

Missing data for the trial product estimand were handled through multiple imputation using the Markov Chain Monte Carlo method, assuming that non-adherent participants would have responded similarly to adherent participants within the same treatment arm

It is also known to lighten the skin by decreasing melanin (the pigment responsible for dark skin) production, resulting in a more even skin tone and fewer dark spots