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Comparing Effectiveness: What the Research Shows Weight Loss Results The SURMOUNT-1 clinical trial comparing tirzepatide directly to a placebo showed remarkable results: Tirzepatide 5mg: Average 15% weight loss Tirzepatide 10mg: Average 19.5% weight loss Tirzepatide 15mg: Average 20.9% weight loss Compare this to semaglutides STEP trials: Semaglutide 2.4mg: Average 14.9% weight loss While both medications produce significant results, tirzepatide shows a statistical advantage, particularly at higher doses

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