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Gastrointestinal symptoms - Diarrhea, constipation, abdominal discomfort, vomiting Reduced appetite - While this contributes to weight loss, some people find it makes eating adequate nutrition challenging Fatigue - Some individuals report feeling more tired, particularly in the first few weeks Injection site reactions - Redness, itching, or mild discomfort at injection sites (for injectable formulations) Most side effects are dose-dependent and tend to improve as the body adjusts

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In addition to weight loss, semaglutide with B12 has been shown to improve other health markers such as blood pressure, cholesterol levels, and blood sugar control

10.1006/abio.2002.5611 Anal