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The implication of these findings is that excess removal of hydrogen peroxide contributes to reductive stress that promotes protein misfolding and aggregation and the resulting cardiac dysfunction

When mutating all but the putative catalytic cysteine (Cys A ) to serines, the remaining Cys21 had a p K a between 6 and 7 (Fig

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At the same time, ellagic acid also prevented the decrease of the mitochondrial membrane potential ( Yet another phenolic acid, rosmarinic acid, has been found to reduce the amount of reactive oxygen species and malondialdehyde, which in turn attenuates cellular oxidative stress and protects hydrogen peroxide-treated glial cells (Lee et al., 2008) on SH-SY5Y (human dopaminergic neuron cells) by controlling the upregulation of Bax and the downregulation of Bcl-2, and reduce mitochondrial membrane potential by reducing reactive oxygen species