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Studies using adult human peripheral T cells demonstrated that glutamate at low concentrations ( 1 mM), however, this effect reversed, indicating that glutamate tends to have immunosuppressive properties at higher concentrations (176, 178)

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(i) An ASC may request an ECE within 60 calendar days of the date that the extraordinary circumstance occurred by submitting the information specified by CMS at QualityNet or a successor website

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