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This effect may be explained by a DPP-4 inhibitor-dependent reduction in intestinal lipoprotein production and consecutive lowering of circulating chylomicrons (36, 37)

Payers, such as insurance companies, look at the clinical effectiveness and real-world evidence to decide which weight loss drugs to reimburse

SURMOUNT-4 (N=670) demonstrated that patients who completed titration and then continued maintenance tirzepatide maintained 18.2% body weight loss at 88 weeks, compared to 2.5% in the withdrawal group [11]

Depending on the substance, these medications are often given by injection, either once a week or once a day