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So to answer your question directly, there are some people who probably don't have that thrifty gene, but just the fact of how their lifestyle is they're not physically active, they're eating a lot of highly processed food and so forth they're gaining weight, but that can change quickly depending upon change in their behavior and in their environment

Since then, several GLP-1 mono-agonists have been approved, along with tirzepatide, the first dual GLP-1 and glucose insulinotropic polypeptide (GIP) receptor agonist

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Though similarities exist in their structure and function, each incretin has some differing effects