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178 Consequently, GLP-1 RAs may help restore mitochondrial homeostasis, potentially through AMPK and sirtuin signaling pathways involved in energy sensing, autophagy, and mitochondrial turnover

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Trial 1 Results at Week 26 in a Monotherapy Trial of Semaglutide Tablets in Adult Patients with Type 2 Diabetes Mellitus Inadequately Controlled with Diet and Exercise a The intent-to-treat population includes all randomized patients

While the results appear promising, Gounder cautioned that longer-term studies are needed