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Fig.2 co-metabolic reaction of GLP-1, GIP and GCG Long-term strategy Long-term transformation strategies for GLP-1 analogue are: 1) Amino acid sequence optimization: Reduce the rapid degradation of DPP-4 enzyme,extend the half-life

Lymphoproliferative disorders include conditions such as non-Hodgkin lymphoma, Hodgkin lymphoma, and chronic lymphocytic leukaemia involving abnormal lymphocyte proliferation

The most common side effects are mild and temporary (nausea, reduced appetite, occasional digestive upset) and we minimise them by starting low and titrating slowly

Dreishpoon MB, Bick NR, Petrova B, Warui DM, Cameron A, Booker SJ, et al