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Metabolism: We have highlighted the minimal hepatic metabolism of sitagliptin, with essentially all of the compound remaining unmetabolized in circulation

Indeed, in CA1 interneurons in the hippocampus, afferent tetanization induced LTD that could spread to nonactivated synapses (McMahon and Kauer, 1997) or induce plastic changes that lack input-specificity with LTP, LTD, or no changes occurring in both homosynaptic and heterosynaptic pathways in all possible combinations (Cowan et al., 1998)

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