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Compound 4 (1.94 g, 2.47 mmol), H-Lys-OMe2HCl (0.24 g, 1.03 mmol), PYBOP (1.62 g, 3.10 mmol) and HOBT (0.42 g, 3.10 mmol) were dissolved in DMF (40 mL) under nitrogen atmosphere and ice bath conditions

The ability of the placenta and fetus to synthesize carnitine suggests that in circumstances when maternal carnitine supply is limited, carnitine biosynthesis by the fetal-placental unit may supply sufficient carnitine for placental and fetal metabolism

Its high selectivity and efficiency facilitate chemical synthesis 15,16 and prodrug activation 17 , holding great potential to reduce off-target toxicity and address multidrug resistance 18,19

These are exemplified by ascorbic acid, thiols (such as thioglycerol and thioglycolic acid), and polyphenols (such as propyl gallate)