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Int J Mol Sci (2021) 22(4):1786

It is especially important for the proper function of hematopoiesis, is involved in the synthesis of DNA and ATP, and is necessary for the proper function of the nervous system and for certain metabolic processes in the body

Research has indicated that the regulatory action of L-citrulline on the protein anabolic metabolism of muscle cells is independent of the insulin and Akt pathways, and it directly regulates muscle protein synthesis in rats via the PI3K/MAPK/4E-BP1 pathway [101] (Figure 4)