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The only long-term trial was discontinued due to a case of fatal myocardial infarction, deemed unrelated to CJC-1295 itself [9]

Redox sensitive human mitochondrial aconitase and its interaction with frataxin: in vitro and in silico studies confirm that it takes two to tango

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555,556 Lifestyle modifications include head-up tilt sleeping, which elevates the head of the bed by 1030 to reduce nocturnal diuresis and improve morning orthostatic tolerance, and advising patients to avoid triggers such as prolonged standing, sudden postural changes, high ambient temperatures, and large meals that may exacerbate symptoms