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Despite broad preclinical support, human data are extremely limited

In this situation, it can be challenging to demonstrate B12 deficiency even when there are typical symptoms (including neuropathy-like paraesthesia and numbness), as serum B12 concentrations may be just within, or sometimes above, the normal range due to the oral supplementation

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Indeed, recent work has likewise implicated cell cycle arrest, induced either by p53 activation or CDK4/6 inhibition, in sensitizing fibrosarcoma cells to GPX4 inhibition 51