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A study evaluating the effectiveness of a 45-day VLEKT in improving acne in 31 young women with moderate acne and grade I obesity showed a reduction in markers of oxidative stress, such as reactive oxygen metabolite derivatives (dROMs), and a decrease in pro-inflammatory metabolites, including trimethylamine N-oxide (TMAO)

Indeed, while some retrospective-case control studies, have shown that metformin is able to reduce overall cancer incidence and mortality by 10%40% (IDF, 2021), RCTs failed to show a significant reduction in cancer incidence and mortality (Stevens et al., 2012

This indicates that TMAO levels represent the bodys inflammatory condition and nutritional status

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