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If budgeting for one intervention, prioritise tirzepatide it has FDA approval and robust Phase 3 evidence for weight loss, whereas glutathione supplementation for metabolic support does not

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Candidate molecules should be selected based on robust, reproducible evidence from well-controlled studies that adequately address PAINS concerns and demonstrate target engagement

A Phase 2 study published in the New England Journal of Medicine in 2023 (Jastreboff et al.) reported substantial weight loss in participants with obesity