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The studies also provided evidence for the concept that increased lipolysis (i agonists, fenofibrate and rosiglitazone, on biomarkers of lipid and glucose metabolism in healthy nondiabetic volunteers

TRIUMPH-1: #retatrutide topline data Phase 3, n=2,339, 80 wk, obesity without diabetes (efficacy estimand): 12 mg: -28.3% body weight (-31.9 kg) 9 mg: -25.9% | 4 mg: -19.0% | Placebo: -2.2% 30% weight loss: 45.3% vs 0.5% 104-wk extension (BMI 35, n=532), 12 mg MTD: -30.3% Cross-trial context (obesity, no diabetes): STEP-1 SEMA 2.4 mg, 68 wk: -14.9% SURMOUNT-1 TZP 15 mg, 72 wk: -20.9% TRIUMPH-1 RETA 12 mg, 80 wk: -28.3% But: Topline press release