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Concurrent medical conditions: Many conditions commonly coexist with type 2 diabetes and cause fatigue, including: Hypothyroidism (underactive thyroid) more common in people with diabetes than in the general population Obstructive sleep apnoea more prevalent in individuals with obesity

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Another major resistance mechanism involves a lineage alteration into AR-indifferent carcinoma such a neuroendocrine which is diagnostically characterized by robust 18 F-FDG uptake and loss of AR signaling