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The absence or presence of publication bias was confirmed through the Eggers test, as shown in Table 1

Investigation of the safety and efficacy of edaravone in 20 ALS patients who received this antioxidant intravenously indicated that this drug is safe and may delay the progression of functional motor disturbances by reducing OS (Yoshino and Kimura, 2006) (Table 1)

The percentage of wound size was calculated as follows: [A (4,8,12,16) /A 0 ] 100%, where A 0 and A (4,8,12,16) represent the wound areas on day 0 and days 4, 8, 12, and 16, respectively