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Cerebrospinal fluid-contacting neurons (CSF-cNs) located in the ependyma have bidirectional communication function between cerebralspinal fluid and brain parenchyma, and may participate in the pathway of iron-induced cognitive dysfunction through projected nerve fibers and transmitted factor, such as 5-hydroxytryptamine, etc

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BAC water includes 0.9% benzyl alcohol as a bacteriostatic preservative, while sterile water has no preservative and saline has sodium chloride instead