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January 2026: MHRA approves Wegovy 7.2mg higher dose narrowing the efficacy gap with Mounjaro to ~1.8 percentage points

Notably, More recent studies suggest that PYY signaling interacts synergistically with GLP-1 and other satiety peptides, raising the possibility that lower-dose combination strategies could harness its anorectic effects while minimizing intolerance ( 5.2 Oxyntomodulin as an endogenous polypharmacologic signal As discussed in Section 4.4, it also plays a central role in appetite regulation in the context of metabolic peptides

GLP-1 medications, HRT, and most supplements are typically out-of-pocket but very reasonable