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[53] [54] This is because it requires significant damage to the liver to impair bilirubin excretion, hence minor impairment (in the absence of biliary obstruction or Gilbert syndrome) would not lead to jaundice

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Despite their effectiveness, high doses of GLP-1 medications can come with a variety of unpleasant side effects, such as nausea, which can make them less appealing as a long-term solution for many patients

Approved ahead of its June 16, 2026 PDUFA target action date, this marks the first time an oral antiviral has been authorized specifically to prevent symptomatic infection following household exposure