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Various factors, including hyperglycemia, lipid accumulation, oxidative stress, hypoxia, RAAS, ER stress, inflammation, EMT and programmed cell death, have been shown to induce renal tubular injury and contribute to the progression of DKD

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To use fat for fuel, your cells have to move long-chain fatty acids into the mitochondria the little "power plants" inside each cell where fat gets burned for energy

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