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ACTH suppression and circadian normalization: Studies by Graf and colleagues (referenced in Ekman 1985 and subsequent reviews) reported that DSIP suppresses ACTH-stimulated cortisol release and appears to normalize disrupted circadian patterns

In fact, GR and FK506 binding protein 5 (FKBP5) expression can be changed by the polyphenolic flavonoid icariin, which enhances GR stability and lessens GR sensitivity to GC in vivo (167)

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This observation aligns well with the crucial ability of viruses to interact with host proteins (for example in the Potyviridae family), leading to the induction and support of virus infection in different hosts (Yang et al., 2021)