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The underlying causes of autism include genetic predisposition, epigenetics, neurological factors, metabolic factors, psychosocial factors, prenatal/postnatal factors, mitochondrial dysfunction, cellular stress, environmental and immunological-inflammatory factors, and the interactions of these factors with each other [9, 10]

(4) Baar MP, Brandt RMC, Putavet DA, Klein JDD, Derks KWJ, Bourgeois BRM, Stryeck S, Rijksen Y, van Willigenburg H, Feijtel DA, van der Pluijm I, Essers J, van Cappellen WA, van IJcken WF, Houtsmuller AB, Pothof J, de Bruin RWF, Madl T, Hoeijmakers JHJ, Campisi J, de Keizer PLJ

Osteoblast function is compromised at sites of focal bone erosion in inflammatory arthritis