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Naliboff BD, Smith SR, Serpa JG, Laird KT, Stains J, Connolly LS, et al

As a result of this, you may experience increased appetite and weight regain

Weight loss results vary, but many individuals experience significant reductions within 12-24 weeks, depending on dosage and adherence to diet and exercise

Figure 2: Mean Percent Change in Body Weight from Baseline in Patients Aged 6 Years with Obesity due to POMC, PCSK1, or LEPR Deficiency by Visit (Trial 3 [N=9] and Trial 4 [N=7]) BL=Baseline (day of first dose) V2 to V3 = variable dose titration period (2 to 12 weeks) V3 to V6 = 10-week open-label treatment period V6 to V8 = 8-week placebo withdrawal period (4 weeks active, 4 weeks placebo) V8 to V12 = 32-week open-label treatment period FV = Final visit