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Neuropharmacology 2023;238:109637.ArticlePubMed 57

[7] While kava appears safe in traditional South Pacific use, caution is advised, especially during pregnancy, for people with preexisting liver conditions, or when combined with alcohol consumption, prescription drugs or dietary supplements

More research is needed to fully understand the implications of NAMPT inhibition and the use of FK866 for potential therapeutic benefits related to aging