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As shown in Figure 3A , under GSH-depleted conditions viability of GSTP1 -transfected cells was significantly higher compared to that of mock cells after treatment with 25 and 50 M AQ-QI or 40 M DEAQ-QI

TNF-, primarily produced by macrophages, promotes the inflammatory response by activating various signaling pathways within osteoclasts, including NF-B, proteases, JNK, and MAPK, thereby inducing the release of multiple cytokines and chemokines and activating immune cells

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Nevertheless, whether cell GLP-1Rinduced cell GLP-1 production is associated with a shift back to an immature developmental stage with celllike properties is unknown and will be a focus of future lineage tracing studies