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For this disease, DPP4 inhibition has gained substantial interest, mostly related to the DPP4 substrate, GLP-1

They are used for chronic weight management and, in some cases, type 2 diabetes management, depending on the specific medication and indication

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However, it is interesting to note that initially 17/42 participants had elevated Blood Urea Nitrogen (BUN)/Creatinine ratios, and after the DMSA it decreased 6% (not significant), so that only 14/42 had elevated levels, and 1/42 had low levels