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doi: 10.1053/j.ajkd.2005.04.010

This represents a significant limitation in the evidence base, as large-scale human trials examining musculoskeletal applications have not been published

For better application of VOA, safety assessment should be given priority

Results Overall and sex-specific associations of genetically predicted l-carnitine with CVD Genetically predicted higher l-carnitine was nominally associated with higher risk of CAD and heart failure in men and women, with odds ratio (OR) 1.07 (95% confidence interval (CI) 1.02 to 1.11) for CAD and OR 1.05 (95% CI 1.01 to 1.09) for heart failure per standard deviation (SD) increase in genetically predicted l-carnitine (Fig