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doi:10.1074/jbc.M509496200

Patch-clamp on pyramidal cells to characterise intrinsic properties (rheobase, adaptation, afterhyperpolarisation)

To ensure people currently taking dulaglutide and liraglutide can continue to access these medicines, new initiations are restricted to people with type 2 diabetes who are high-risk and have no other appropriate treatment options

Having cleared the hurdle as a treatment for diabetes, the FDA then approved semaglutide, marketed as Wegovy, for obesity in 2021, and then in Europe the following year