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Evidence-based autoimmune disease treatments include disease-modifying antirheumatic drugs (DMARDs) like methotrexate, biologic agents targeting specific inflammatory pathways (TNF- inhibitors, IL-6 inhibitors), JAK inhibitors, corticosteroids for acute flares, and immunomodulators

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Patients with pre-existing gallbladder sludge or small asymptomatic gallstones detected on imaging may be at higher risk for progression to symptomatic disease during treatment