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Importantly, genetic loss-of-function, rescue, and pharmacological inhibition analyses further demonstrated that intact MAPKAPK2 kinase activity, rather than protein expression alone, is indispensable for maintaining melanocyte resistance to oxidative stress

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Another proof of this was that motor fluctuations in PD patients improved after SIBO eradication, hence providing more support of the association between SIBO and motor fluctuations (Lubomski et al., 2020)