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Clinical studies show significant correlations between CSF levels of HMGB1/IL-1 and SN necrosis in PD patients, confirming neuroinflammatory synergy with necrosis [188]

In oral allergy syndrome, also known as pollen-food allergy syndrome (PFAS or PFS), IgE antibodies produced against plant pollens cross-react with proteins in raw fruits, vegetables, and nuts, which leads to itching and swelling of the mouth, lips, face, tongue, and throat soon after eating