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The authors said: In this 72-week trial in participants with obesity, tirzepatide once weekly provided substantial reductions in body weight, consistent across all BMI categories, with improvement in body composition that was clinically meaningful and consistent across age groups. Dr Louis Aronne, from Weill Cornell Medicine in New York and a consultant to Eli Lilly, who presented the findings, said there was a need to understand the effect of weight loss on fat mass and lean mass, particularly in the elderly

In a Phase 2 trial, adults with obesity lost about 24% of their body weight after 48 weeks, the largest drop reported for this class so far

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