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In both structures, Lys26 interacted with Glu128 of the GLP-1R, despite previous receptor mutagenesis studies suggesting that this interaction was not important and that acylation of Lys26 had only a minor impact on receptor affinity
Other proposed mechanisms include potential effects on cardiac ion channels and alterations in baroreceptor sensitivity , though these remain speculative in humans
Furthermore, it appears to increase GLP1R expression (promoting more GLP-1 receptors) and reduce DPP4 expression (maintaining more active GLP-1)
[39].Bydureon BCise (exenatide sustained-release) for injectable suspension [prescribing information]
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