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A clinical trial by Krger et al

Common causes of temporary post-injection pain include: Local inflammation: The injection itself can irritate surrounding tissues Increased joint pressure: The added fluid volume temporarily stretches the joint capsule Normal healing response: Your bodys natural reaction to any needle puncture Muscle tension: Protective guarding around the injection site According to Cleveland Clinic, this reaction typically manifests as mild pain and swelling at the injection site and resolves without intervention [3]

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Nevertheless, pharmacological treatment is the first choice of therapy to improve symptoms, using psychostimulants such as methylphenidate (MPH) and amphetamines, which inhibit the reuptake of dopamine and norepinephrine, thus increasing catecholaminergic activity in the prefrontal cortex, striatum, and hippocampus, improving symptoms [6,17]