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Data availability The following data sets were generated The following previously published data sets were used References Article and author information Author details Liou Y Sun Department of Internal Medicine, Southern Illinois University School of Medicine, Springfield, United States Contribution LYS, Conception and design, Acquisition of data, Analysis and interpretation of data, Drafting or revising the article, Contributed unpublished essential data or reagents Contributed equally with Adam Spong For correspondence [email protected] Competing interests The authors declare that no competing interests exist