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To more directly test for a potential microbial contribution to the observed d9-carnitine in plasma following d9-BB ingestion, we quantified the production of d9-carnitine (and d9-betaine) from d9-BB in freshly harvested gut segments incubated ex vivo under either aerobic or anaerobic conditions

As a result, the expression levels of KRT27 and KRT28 , which are essential for the proper assembly of type I and II keratin protein complexes and formation of keratin intermediate filaments in the IRS, were significantly higher in the KO group (Fig