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Another concern is that the drugs could quash reward signalling generally in the brain

Avoid use of phentermine and topiramate extended-release capsules in patients with end-stage renal disease on dialysis

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Specifically, retatrutide is intended to activate the glucagon-like peptide-1 (GLP-1) receptor, the glucose-dependent insulinotropic polypeptide (GIP) receptor, and the glucagon receptor a combination that distinguishes it from existing approved therapies such as semaglutide (a GLP-1 receptor agonist) or tirzepatide (a dual GIP/GLP-1 receptor agonist)