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Its mechanism centers on direct pineal gland function enhancement, melatonin production optimization , and circadian clock gene expression modulation

[10] [9] A skeptical reading is available and should be stated: an intervention whose reported benefits appear late, persist for a day, and continue after discontinuation is an intervention whose reported benefits are difficult to distinguish from expectation, regression to the mean, and the substantial placebo response that characterizes insomnia research generally

Throughout, "dose," "protocol," and "cycle" describe what is documented in research and community protocols, not clinical prescriptions

E., Zhu, S