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We focus specifically on how the dysregulation of this network drives pathogenic Th17/Treg imbalance across diverse autoimmune diseases, including rheumatoid arthritis (RA), multiple sclerosis (MS), inflammatory bowel disease (IBD), and systemic lupus erythematosus (SLE)

The transappendageal delivery follows the penetration through a diffusional shunt provided by the hair follicles or the pilosebaceous unit [290, 322]

All categorical variables are expressed as number and percentage of counts

Following centrifugation (20,000 x g at 4 C for 10 min), supernatants were collected, and sample protein concentrations were determined using Pierce BCA Protein Assay Kit (Thermo Scientific, 23225) with bovine serum albumin as a protein standard