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Human Studies This is where investigations are tested on living human beings

That said, DEXA is certainly imperfect in splicing the details of this body composition change as adipose tissue includes plenty of lean mass. Additionally, the placebo group lost more lean mass (-1.83kg) than fat mass (1.37kg), which shows potential error. Nadolsky pointed out that rapid weight loss, in general, will reduce resting metabolic rate to some degree

However, following ingestion of a large overdose (150 mg/kg or greater) the glucuronide and sulfate conjugation pathways are saturated resulting in a larger fraction of the drug being metabolized via the P-450 pathway