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A preliminary trial for the efficacy of TZT in the management of T2DM showed that this drug was less effective compared to semaglutide (an analogue of GLP-1) in the reduction of insulin resistance (IR) and glycated hemoglobin (HbA 1c ) (Fras et al

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First, the GIP pathway may drive metabolic improvements, improved fat oxidation , better lipid metabolism, enhanced insulin sensitivity, that contribute to weight loss independently of conscious appetite changes

In clinical trials, approximately 50% of participants achieved at least 15% body weight reduction, and roughly 30% achieved 20% or greater reduction at the highest doses